As noted in a recent Minnesota Public Radio report, synthetic drugs can also be made into liquid form and consumed with a vapor pen or electronic cigarette. When used with synthetic drugs, the vapor produces little to no odor, making it difficult to detect. These vapors are purchased as a liquid form of synthetic cannabinoid and marketed under many names, including Cloud Nine, Purple Diesel, Blue Blossom and Crown.

This form of synthetic drug use is still new and little public research has been conducted on the topic. These products ultimately have an untracked, unregulated manufacturing process and even in vapor form, pose serious health risks such as vomiting, rapid heart rate, hallucinations and psychoses.