Polysubstance use, prescribed or not, can have unpredictable and dangerous effects. Each substance affects the body differently, and combining them increases the potential threat.

Polysubstance use can happen by accident when taking illegal substances. It can also happen on purpose.

Some people may mix one stimulant with another stimulant to increase their effect. The same can happen with mixing multiple depressants. There’s also danger when stimulants and depressants are combined. Combining stimulants with depressants, such as methamphetamine and alcohol, can amplify the effects of both.